Overcoming inhibition
نویسندگان
چکیده
منابع مشابه
Overcoming potassium-mediated triplex inhibition.
Sequence-specific duplex DNA recognition by oligonucleotide-directed triple helix formation is a possible approach to in vivo gene inhibition. However, triple helix formation involving guanine-rich oligonucleotides is inhibited by physiological ions, particularly K+, most likely due to oligonucleotide aggregation via guanine quartets. Three oligodeoxynucleotide (ODN) derivatives were tested for...
متن کاملOvercoming Chemoresistance of Pediatric Ependymoma by Inhibition of STAT3 Signaling
The long-term clinical outcome of pediatric intracranial epepdymoma is poor with a high rate of recurrence. One of the main reasons for this poor outcome is the tumor's inherent resistance to chemotherapy. Signal transducer and activator of transcription 3 (STAT3) is overactive in many human cancers, and inhibition of STAT3 signaling is an emerging area of interest in oncology. In this study, t...
متن کاملOvercoming resistance to BRAF inhibition in BRAF-mutated metastatic melanoma
Almost 50% of metastatic melanoma patients harbor a BRAF(V600) mutation and the introduction of BRAF inhibitors has improved their treatment options. BRAF inhibitors vemurafenib and dabrafenib achieved improved overall survival over chemotherapy and have been approved for the treatment of BRAF-mutated metastatic melanoma. However, most patients develop mechanisms of acquired resistance and abou...
متن کاملMAG, myelin and overcoming growth inhibition in the CNS
While neurons in the central nervous system (CNS) have the capacity to regenerate their axons after injury, they fail to do so, in part because regeneration is limited by growth inhibitory proteins present in CNS myelin. Myelin-associated glycoprotein (MAG) was the first myelin-derived growth inhibitory protein identified, and its inhibitory activity was initially elucidated in 1994 independent...
متن کاملOvercoming the Fear of Lecture
نقش ما در مراقبتهای بهداشتی، توسعه مهارتهای مراقبتی از بیماران است و این متضمن داشتن قدرت بیان مؤثر است، این قدرت بیان را نه تنها در جمع همکاران بلکه باید در جلسات نیز داشت، آنهم نه در برابر پنج نفر بلکه در برابر پانصد نفر، که این تسلط بیان را نه تنها هنگامی که شرایط مساعد است، بلکه به هنگام مناقشه و جر و بحث نیز باید دارا بود.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2004
ISSN: 1474-1776,1474-1784
DOI: 10.1038/nrd1354